Mouse anti-NSP-C, clone RNL-4, Purified (Monoclonal)

Clone Number: RNL-4

Immunogen: synthetic peptide encompassing the unique 20 N-terminal amino acid sequence of Reticulon-1C

Concentration: 1 mg/ml

Storage buffer: PBS with 0.09% sodium azide

Additional info: In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is sofar not found in Human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).RNL-4 reacts with peripheral nerves and ganglia of various tissues and cross-reacts with smooth muscle cells and myoepithelium. In the central nervous system it reacts with the neurohypophysis and pars intermedia of the pituitary gland, and a weak diffuse staining was observed in neurons of the granular and molecular layer of the cerebellar cortex, while glial cells, cerebellar medulla and Purkinje cells are negative. Reticulon-1 has been found to indicate neuronal differentiation and to be downregulated in neurological pathologies.

References: Senden et al. Eur J Cell Biol 1996;69:197-213/Senden et al. J Pathol 1997;182:13-21/Hens et al. Cell Tissue Res 1998;292:229-237

• Artikelnummer: SANMON2097
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON2097
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Rat (Rattus), Pig (Porcine)
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western Blotting, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG1
• Wirt: Mouse