Mouse anti-P16, clone DSC-50 (Monoclonal)

Clone Number: DCS-50

Immunogen: Recombinant human p16 protein

Concentration: n/a

Storage buffer: Lyophilized; reconstitute in 1 ml dist. water (final solution contains 0.09% sodium azide, 0.5% BSA in PBS buffer, pH 7.4)

Additional info: p16 (CDKN2A, p16Ink4A), is key regulator of the cell cycle and involved in cell cycle control and cellular senescence. It is a specific inhibitor for Cdk4 and Cdk6 and binds to the phosphorylated Cdk-cyclin complex. A disruption of this pathway is commonly observed in cancer. p16 is lost in the majority of tumor cell lines and in most primary tumors. It is not expressed in melanoma.

References: Wiest, T. et al. Oncogene 2002;21: 1510–1517 /Shibata, K. R. et al. Stem Cells 2007; 25: 2371–82 /Lukas, J. et al. Nature 1995;375: 503–506

• Artikelnummer: SANMON9131
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON9131
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), Western Blotting, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse