Mouse anti-p53, clone BP53-12 (Monoclonal)

Clone Number: BP53-12

Immunogen: Bacterially expressed full-length wild-type p53

Concentration: 1 mg/ml

Storage buffer: Phosphate buffered saline (PBS) solution with 15 mM sodium azide

Additional info: The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest, or proteins that trigger apoptosis, such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain, central DNA-binding domain, oligomerisation domain, and C-terminal regulatory domain. There are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization.

• Artikelnummer: SANMON7015
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON7015
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human, Primate
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin), Immunoprecipitation, Western Blotting, ELISA, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG2a
• Wirt: Mouse