Rat anti-Mouse JAM-1, clone BV12 (Monoclonal)

Clone Number: BV12

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The monoclonal antibody BV12 recognizes junctional adhesion molecule-A (JAM-A), also known as JAM-1 and the mouse platelet F11-Receptor (F11R), is a cell adhesion molecule (CAM). JAM-A is a member of the immunoglobulin superfamily found on the surface of mouse platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-B (VE-JAM or JAM-3) and JAM-C (JAM-2) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. In human JAM-A plays a role in platelet aggregation, secretion, adhesion and spreading.

References: Bazzoni; G et al. J Biol Chem 2000; 275: 20520 /Martinez-Estrada, O et al Am J Physiol Lung Cell Mol Physiol 2005, 288: L1081

• Artikelnummer: SANMON2069
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON2069
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunoprecipitation, Western Blotting, Flow Cytometry
• Isotyp: IgG2a
• Wirt: Rat