Mouse anti-SHIP1 Purified, clone SHIP-01 (Monoclonal)

Clone Number: SHIP-01

Immunogen: Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.

Concentration: 1 mg/ml

Format: Purified by protein-A affinity chromatography.

Storage buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Additional info: SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5´inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.SpecificityThe antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein. The epitope sequence is highly conserved and reactivity with multiple species is expected.Application detailsFlow cytometry: Intracellular staining; recommended dilution: 2-5 μg/ml; positive control: human blood leukocytes.
Western blotting: Positive control: RAMOS human cell line, reducing conditions.

• Artikelnummer: SANMON23306
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON23306
• Green Labware: Nein
• Verpackungseinheit: 0,1 mg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting, Flow Cytometry
• Isotyp: IgG2a
• Wirt: Mouse