Mouse anti-SOX-11, clone MRQ-58

Clone Number: MRQ-58

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: n/a

Storage buffer: Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide

Additional info: SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination. Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL). Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1), an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t(11;14)(q13;q32).

References: Hargrave, M et al. Dev Dyn 1997; 210:79-86/Zeng W, et al. Am J Surg Pathol 2012; 36:214-9/Salaverria, I et al. Haematologica 2006; 91:11-6

• Artikelnummer: SANMON-RTU1278
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON-RTU1278
• Green Labware: Nein
• Verpackungseinheit: 7 ml
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (paraffin)
• Isotyp: IgG1
• Wirt: Mouse