Mouse anti-Tumor Necrosis factor Alpha, clone 52B83 (Monoclonal)

Clone Number: 52B83

Immunogen: Unknown or proprietery to MONOSAN and/or its suppliers

Concentration: 100 ug/ ml

Storage buffer: PBS with 0.1% BSA and 0.02% sodium azide

Additional info: The monoclonal antibody 52B83 reacts with tumor necrosis factor alpha (TNF-alpha). TNF-alpha is a homotrimeric 17 kDa protein, that interacts with either one of the two types of TNF-receptors, termed I and II, leading to receptor cross-linking and signal transduction. The receptors differ strongly in their intra-cellular signaling pathways.
TNF-alpha was originally described as a highly cytotoxic cytokine for tumor cells, it causes tumor necrosis in vivo and shows cytolytic activity against tumor cells in vitro. Furthermore,- TNF-alpha is found to be a central mediator in many inflammatory and immunological processes. It can be induced by various products of micro-organisms and by various cytokines leading to expression of a wide variety of- cytokines. The pro-inflammatory properties of- TNF-alpha play a central role in several auto-immune diseases such as rheumatoid arthritis and inhibition by neutralizing molecules have been shown to be beneficial in patients.

References: Bradding; P et al. Am J Respir Cell Mol Biol 1994; 10: 471/Bradding, P et al: Clin Exp Allergy 1995, 25: 406/Gerspach; J et al. Microsc Res Tech 2000; 50: 243

• Artikelnummer: SANMON5006
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON5006
• Green Labware: Nein
• Verpackungseinheit: 1 ml
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rhesus Monkey (Primate), Guinea Pig
• Klonalität: Monoclonal
• Methode: Immunohistochemistry (frozen), Western Blotting, ELISA, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse