Mouse anti-WAF1/p21 protein, clone WA-1 (Monoclonal)

Clone Number: WA-1

Immunogen: human p21 protein

Concentration: 100 ug/ml

Storage buffer: PBS with 0.02% sodium azide

Additional info: WA-1 reacts with human and other mammalian p21, a tumor suppressor protein, belonging to the CDI family. The intracellular protein p21 is a 21 kDa protein, also known as wild-type p53-activated fragment 1 (WAF1). It is an inhibitor of cyclin-dependent kinases (Cdks) and of proliferating-cell nuclear antigen (PCNA). It is induced by wild type p53, but not by mutated p53, by mezerein (anti-leukemic compound) and by interferon-ß. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma and thyroid carcinoma).

References: Kovaric, J. et al, Int. J. Oncol. 9(suppl.), 835 (1996)

• Artikelnummer: SANMON7048
• Hersteller: Sanbio / Monosan
• Hersteller Artikelnummer: MON7048
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Primate, Monkey (Primate)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Immunohistochemistry (frozen), Immunohistochemistry (paraffin), ELISA, Flow Cytometry
• Isotyp: IgG1
• Wirt: Mouse