MYCi975, CAS 2289691-01-4

Formulation: A solid

Formal Name: 4′-chloro-6-[(4-chlorophenyl)methoxy]-3-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]-3′-(trifluoromethyl)-[1,1′-biphenyl]-2-ol

Purity: ≥98%

Formula Markup: C25H16Cl2F6N2O2

Formula Weight: 561,3

Shelf life (days): 1460

CAS Number: 2289691-01-4

Notes: MYCi975 is an inhibitor of the protein-protein interaction between Myc and Myc-associated factor X (MAX).{68661} It binds to Myc (Kd = 2.75 µM) and increases GSK3β-mediated Myc phosphorylation in a cell-free assay. MYCi975 (5 and 10 µM) decreases the viability of MyC-CaP and LNCaP prostate cancer cells. It induces apoptosis in a panel of 11 breast cancer cell lines when used at a concentration of 10 µM.{68662} In vivo, MYCi975 (100 mg/kg) reduces tumor volume in a MyC-CaP mouse xenograft model.

• Artikelnummer: CAY39622-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39622-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK