Mycophenolate mofetil, CAS 128794-94-5

Inosine monophosphate dehydrogenase inhibitor

Product Type: Inhibitor

CAS No.: 128794-94-5

MolecularFormula: C23H31NO7

Molecular Weight: 433,5

Source: Synthetic

Purity: >98% (TLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (40 mg/ml); or ethanol (4 mg/ml)

Appearance: White powder

PubChem CID: 5281078

Scientific Background: Mycophenolate mofetil is an immunosuppressive agent useful in prevention of organ allograft rejection (1). It is metabolized to mycophenolic acid in vivo, which acts by inhibiting the biosynthesis of guanine nucleotides via inhibition of inosine 5’-monophosphate dehydrogenase, suppressing the production of proinflammatory cytokines, nitric oxide and LDH in macrophages (2,3). It also inhibits IL-2-dependent T cell proliferation (4), and microglial and astrocytic activation reducing cell death after neuronal injury (5). It also prevents neuroinflammation.

References: 1. Allison A.C., and Eugui, E.M. (1996) Clin. Transplant. 10:77.2. Jonsson C.A., et al., (2002) Cell. Immunol. 216:93.3. Allison A.C., et al., (1993) Ann. NY Acad. Sci. 696:63.4. Quemeneur J., et al., (2002) J. Immunol. 169:27475. Ebrahimi F., et al., (2012) J. Neuroinflammation 9:89.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-568-50MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-568-50MG
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK