Mycro 3, CAS 944547-46-0

Formulation: A solid

Formal Name: 5-[[[7-(chlorodifluoromethyl)-5-(2-furanyl)pyrazolo[1,5-a]pyrimidin-2-yl]carbonyl]amino]-1-phenyl-1H-pyrazole-4-carboxylic acid, ethyl ester

Purity: ≥95%

Formula Markup: C24H17ClF2N6O4

Formula Weight: 526,9

Shelf life (days): 1460

CAS Number: 944547-46-0

Notes: Mycro 3 is an inhibitor of the protein-protein interaction between c-Myc and c-Myc associated protein (Max; IC50 = 40 µM).{72104} It is also an inhibitor of Max dimerization (IC50 = 88 µM). Mycro 3 selectively reduces the viability of c-Myc-expressing TGR-1 fibroblasts over c-Myc-null HO15.19 fibroblasts (IC50s = 0.25 and 9 µM, respectively).{72105} It decreases tumor weight in PANC-1 and MIA PaCa-2 pancreatic cancer mouse xenograft models when administered at a dose of 100 mg/kg per day. Mycro 3 (5 mg/kg every three days), in combination with docetaxel (Item No. 11637) or abiraterone (Item No. 9002768), reduces tumor volume and improves survival in an LNCaP prostate cancer mouse xenograft model.{72106}

• Artikelnummer: CAY37767-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37767-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK