Myr-Tat-CBD3 (trifluoroacetate salt)

Formulation: A solid

Formal Name: N-myristoyl-L-tyrosylglycyl-L-arginyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-glutaminyl-L-arginyl-L-arginyl-L-arginyl-L-alanyl-L-arginyl-L-seryl-L-arginyl-L-leucyl-L-alanyl-L-α-glutamyl-L-leucyl-L-arginylglycyl-L-valyl-L-prolyl-L-arginylglycyl-L-leucine, trifluoroacetate salt

Purity: ≥95%

Formula Markup: C148H269N59O33 • XCF3COOH

Formula Weight: 3403,1

Shelf life (days): 1460

Notes: Myr-Tat-CBD3 is an inhibitor of the protein-protein interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2).{64987} It inhibits the Cav2.2-CRMP2 interaction by approximately 81% when used at a concentration of 10 µM and inhibits potassium-induced calcium influx in primary rat dorsal root ganglion (DRG) neurons (IC50 = ~2.8 µM). Myr-Tat-CBD3 (20 µM) inhibits calcium, but not sodium, currents in primary DRG neurons. Intrathecal administration of myr-Tat-CBD3 (20 µg/5 µl) prevents carrageenan-induced decreases in paw withdrawal latencies in rats. Myr-Tat-CBD3 decreases cue-induced reinstatement of cocaine-seeking behavior in rats.{64988}

• Artikelnummer: CAY37465-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37465-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe