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Applications: Ideal as a substrate for methylation or acetylation assays or for screening small molecule inhibitors of epigenetic enzymes in drug discovery and HTS applications.
Description: Human core histones (twocopies each of H2A, H2B, H3, and H4),purified from cultured HeLa cells. Histonesare separated from DNA under high saltconditions.
Format: An aqueous solution; sufficient for 50 reactions in a 96- well format
Formulation: 50 mM sodium phosphatebuffer, pH 6.8 and 2.5 M NaCl
Host Cell Line: HeLa cells
Storage Stability: At least 6 months at -80°C.
Supplied As: An aqueous solution
Warnings: Avoidfreeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Meagher, R.B., Mussar, K.J., Epigenetics Chromatin 2012 Jul 20;5(1):11.
2. Huang, H., et al., Biosystems 2012 Aug;109(2):214-9.
3. Zhang, Y., et al., Genes and Dev. 2001; 15: 2343-2360.