Natural Product-like Library

Description: Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.
Natural products are an attractive source with varied structures that exhibit potent biological activities, and desirable pharmacological profiles. The core scaffold of a natural product can also provide a biologically validated framework upon which to display diverse functional groups. Inspired by bioactive natural products, natural product-like compounds, occupying the same chemical space, are ideally suited to explore and to facilitate understanding of biological pathways.
MCE 5K Natural Product-like Compound Library consists of 5,000 natural product-like compounds. Each compound has scaffold of natural products or Tanimoto coefficient >0.6 with natural products. The natural-likeness scoring of these compounds is >-2. What’s more, compounds in the library are drug-like and readily available for re-supply, making it a powerful tool for new drug research and development. It can be widely applied in high-throughput screening (HTS) and high-content screening (HCS).

Advantages:

• A unique collection of natural product-like compound library.
• Each molecule contains scaffold of natural products or has a Tanimoto similarity coefficient greater than 0.6 with 40K natural products, and natural-likeness scoring is more than -2.
• Compatible with “Lipinski” s Rule of Five”, with multiple characteristics such as calculated good permeability (-3.2
• Passed all associated MedChem filters, particularly pan assay interference compound (PAINS) motifs, to remove any inappropriate chemical structures and avoid false hits.
• All compounds are available off the shelf. Pre-plates of 10 mM DMSO solutions, convenient to use.
• NMR and HPLC validated to ensure high purity and quality.

• Artikelnummer: MEXHY-L905-2x100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-L905-2x100
• Verpackungseinheit: 2 x 100 µl
• Mengeneinheit: PAK