NaVbeta3 Antibody, Clone N396/29: APC

Mouse Anti-Rat Nav beta 3 Monoclonal IgG2B

Target: NaVbeta3

Conjugate: APC

Product Type: Monoclonal

Clone Number: N396/29 (Formerly sold as S396-29)

Immunogen: Fusion protein amino acids 1-215 (full-length) of rat NavBeta3

Swiss-Prot: Q9JK00

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~40kDa. Does not cross-reat with NavBeta1, Navbeta2, or Navbeta4.

Cellular Localization: Membrane

Scientific Background: Nav Beta 3 (SCN3B) belongs to the voltage-gated sodium channel group, and modulates channel gating kinetics. It inactivates the sodium channel opening more slowly than its Beta1 subunit. It is also unique in causing persistent sodium currents which are thought to amplify summation of synaptic imputs which is likely to increase the excitability of specific neurons to their individual inputs (2). Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (1, 2). Defects in SCN3B are the cause of Brugada syndrome (3).

References: 1. Genes and mapped phenotypes. (n.d.). Retrieved March 26, 2015, from http://www.ncbi.nlm.nih.gov/gene/?term=Q9jK002. Qu Y., et al. (2001) Mol Cell Neurosci. 18(5): 570-580.3. Ishikawa T., et al. (2013) Circ J. 77(4): 956-967.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-490D-APC
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-490D-APC
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG2b
• Human Gene ID: 245956
• Wirt: Mouse