Abbreviation: NBS1/NBN
Target Synonym: NBN; AT-V1; AT-V2; ATV; NBS; NBS1; P95; nibrin
Conjugation: Unconjugated
UNIProt ID: O60934
Background: Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
Concentration: 1mg/mL
Immunogen: A synthetic peptide of human NBS1/NBN
Dilution: WB 1:500-1:2000,IF 1:50-1:200