NCH-51, CAS 848354-66-5

Formulation: A crystalline solid

Formal Name: S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester, 2-methyl-propanethioic acid

Purity: ≥98%

Formula Markup: C20H26N2O2S2

Formula Weight: 390,6

Shelf life (days): 1460

CAS Number: 848354-66-5

Notes: NCH-51 is an inhibitor of histone deacetylases (HDACs) with IC50 values of 48, 32, and 41 nM for HDAC1, 4, and 6, respectively.{41830} It increases acetylation of histone H4 and α-tubulin in HCT116 cells when used at concentrations ranging from 1 to 25 µM and inhibits the growth of a variety of cancer cell lines (EC50s = 1.1-9.1 µM).{41831,41832} NCH-51 (0.4-1.6 µM) also induces HIV-1 viral replication in OM10.1 and ACH-2 cells latently infected with HIV-1 when used alone and, to a greater effect, when used in the presence of TNF-α, with cytotoxic concentration (CC50) values of approximately 2 µM for both cell lines.{41830}

• Artikelnummer: CAY21234-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 21234-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe