Necrostatin-34, CAS 375835-43-1

Formulation: A solid

Formal Name: 2-[[3-cyano-1,4,5,6-tetrahydro-4-(4-methylphenyl)-6-oxo-2-pyridinyl]thio]-N-2-thiazolyl-acetamide

Purity: ≥98%

Formula Markup: C18H16N4O2S2

Formula Weight: 384,5

Shelf life (days): 1460

CAS Number: 375835-43-1

Notes: Necrostatin-34 is an inhibitor of receptor-interacting serine/threonine kinase 1 (RIPK1; IC50 = 5.5 µM).{66361} It inhibits TNF-α-induced necroptosis in Jurkat cells lacking Fas-associated death domain protein (FADD) and L-929 cells (IC50s = 6.67 and 1.35 µM, respectively). Necrostatin-34 (10 µM) inhibits necroptosis induced by the chemical inducer of dimerization for FK506 binding protein (FKPB) fusion proteins AP20187 (Item No. 36808) and the pan-caspase inhibitor Z-VA-DL-D(OMe)-FMK (zVAD-FMK; Item No. 27421) in L-929 cells expressing an FKBP and RIPK1 fusion protein.

• Artikelnummer: CAY37735-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37735-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe