Necrostatin, CAS 4311-88-0

Necroptosis inhibitor

Product Type: Inhibitor

CAS No.: 4311-88-0

MolecularFormula: C13H13N3OS

Molecular Weight: 259,33

Source: Synthetic

Purity: >98%

Solubility: Soluble to 15 mM in ethanol, and to 30 mM in DMSO

Appearance: Light Yellow Solid

PubChem CID: 2828334

Scientific Background: Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).

References: 1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573.2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714.3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-213-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-213-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Reaktivität: Human