NEDD8 Inhibitor M22, CAS 864420-54-2

Formulation: A solid

Formal Name: N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine

Purity: ≥98%

Formula Markup: C20H24Cl2N2

Formula Weight: 363,3

Shelf life (days): 1460

CAS Number: 864420-54-2

Notes: NEDD8 inhibitor M22 is an inhibitor of NEDD8-activating enzyme (NAE).{65669} It inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay using recombinant human NAE in a concentration-dependent manner. NEDD8 inhibitor M22 selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 non-small cell lung cancer (NSCLC) cells and inhibits the growth of A549 cells (GI50 = 5.5 µM). It inhibits tumor growth in an AGS gastric adenocarcinoma mouse xenograft model when administered at a dose of 60 mg/kg.

• Artikelnummer: CAY37756-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37756-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: Reinstoffe