Neratinib, CAS 698387-09-6

Formulation: A crystalline solid

Formal Name: (2E)-N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-4-(dimethylamino)-2-butenamide

Purity: ≥98%

Formula Markup: C30H29ClN6O3

Formula Weight: 557

Shelf life (days): 1460

CAS Number: 698387-09-6

Notes: Neratinib is a dual inhibitor of EGFR and HER2 (IC50s = 92 and 59 nM, respectively).{30796} It is selective for EGFR and HER2 over a panel of 12 kinases (IC50s = >5,000 nM) but does inhibit VEGFR2 and Src (IC50s = 800 and 1,400 nM, respectively). Neratinib inhibits the proliferation of NCI H508 colorectal cancer cells expressing wild-type or mutant forms of HER2 (IC50s = 0.2-3 nM).{30794} It reduces tumor growth in BT474 breast and SKOV3 ovarian cancer mouse xenograft models when administered at a dose of 40 mg/kg.{30796} Formulations containing neratinib have been used in the treatment of breast cancer.

• Artikelnummer: CAY18404-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18404-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK
• Methode: Reinstoffe