NFkB p105 antibody (HL1784)

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Clone Name: HL1784

Light Chain: Kappa

Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 105

Form: Liquid

Buffer (with preservative): PBS, no preservative.

Concentration: 2 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]

Uniprot ID: P19838

Antigen Species: Human

Immunogen: Recombinant protein encompassing a sequence within the center region of human NFkB p105. The exact sequence is proprietary.

Purification: Affinity purified by Protein A.

Conjugation: Unconjugated

Full Name: nuclear factor kappa B subunit 1

• Artikelnummer: GTX637436-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX637436-100
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Recombinant
• Methode: Western Blotting
• Isotyp: IgG
• Human Gene ID: 4790
• Wirt: Rabbit
• Konjugat: Unconjugated