NLG919, CAS 1402836-58-1

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Biological Activity: NLG919 potently blocks IDO-induced T cell suppression and restored Tcell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration ofplasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced theantitumor responses of naÍve, resting pmel-1 T-cells to vaccination with cognate hgp100 peptideplus CpG-1826 in IFA in mice bearing B16F10 tumors.

CAS Number: 1402836-58-1

Description: NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer.

Format: White powder

Purity: ≥98%

Solubility: Soluble in DMSO at 15 mg/ml.

Storage Stability: Store as supplied at or below -20°C for up to 3 years. Stable in DMSO at-80°C for up to 6 months.

Biosafety Level: Not applicable (BSL-1)

References: 1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195.
2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250.

• Artikelnummer: BPS27337-2
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27337-2
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK