NLRP3 antibody (HL2813)

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Clone Name: HL2813

Light Chain: Kappa

Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 118

Form: Liquid

Buffer (with preservative): PBS, no Preservative.

Concentration: batch dependent (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]

Uniprot ID: Q96P20

Antigen Species: Human

Immunogen: Synthetic peptide of human NLRP3.

Purification: Affinity purified by Protein A.

Conjugation: Unconjugated

Full Name: NLR family pyrin domain containing 3

• Artikelnummer: GTX639954-S-25
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX639954-S-25
• Verpackungseinheit: 25 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Monoclonal
• Methode: Western Blotting
• Isotyp: IgG
• Human Gene ID: 114548
• Wirt: Rabbit
• Konjugat: Unconjugated