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NLRP3 antibody (HL2813)
NLRP3 antibody (HL2813)
Artikelnummer
GTX639954-S-25
Verpackungseinheit
25 μl
Hersteller
GeneTex
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Clone Name: HL2813
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 118
Form: Liquid
Buffer (with preservative): PBS, no Preservative.
Concentration: batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
Uniprot ID: Q96P20
Antigen Species: Human
Immunogen: Synthetic peptide of human NLRP3.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: NLR family pyrin domain containing 3
Light Chain: Kappa
Application Note: WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 118
Form: Liquid
Buffer (with preservative): PBS, no Preservative.
Concentration: batch dependent (Please refer to the vial label for the specific concentration.)
Background: This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Oct 2008]
Uniprot ID: Q96P20
Antigen Species: Human
Immunogen: Synthetic peptide of human NLRP3.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: NLR family pyrin domain containing 3
| Artikelnummer | GTX639954-S-25 |
|---|---|
| Hersteller | GeneTex |
| Hersteller Artikelnummer | GTX639954-S-25 |
| Green Labware | Nein |
| Verpackungseinheit | 25 μl |
| Mengeneinheit | STK |
| Reaktivität | Human, Mouse (Murine) |
| Klonalität | Monoclonal |
| Methode | Western Blotting |
| Isotyp | IgG |
| Human Gene ID | 114548 |
| Wirt | Rabbit |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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