NLRP3 (NALP3) (GKT(231-233)AAA), His-Flag-Tags (HEK293-derived) Recombinant

Products from BPS Bioscience require a minimum order value above 400€

Encompassing Amino Acids: 2-1036 (end)

Description: Human NLR Family Pyrin Domain Containing 3 (NLRP3), also known as NALP3, Cold Autoinflammatory Syndrome 1 Protein (CIAS1), cryopyrin and PYPAF1 (Genbank Accession No. NM_004895), a.a. 2-1036(end), with N-terminal His-FLAG-tag and with GKTAAA mutations at 231-233, expressed in a HEK293 expression system. MW = 120 kDa.

Format: Aqueous buffer solution

Formulation: 40 mM Tris-HCl pH 8.0, 110 mM NaCl, 2.2 mM KCl, 10 ng/µL Flag peptide, 3 mM DTT, and 20% glycerol

Genbank: NM_004895

Storage Stability: At least 6 months at -80°C. Protein may be diluted to ≥ 100 µg/ml in PBS + glycerol and stored at -80°C.

Tags: N-terminal His-FLAG-tag

Uniprot: Q96P20

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Kummer, J.A., J. Histochem. Cytochem., 2007 May; 55(5):443-52.2. Manji, G.A., J. Biol. Chem. 2002 Mar 29; 277(13):11570-5. Application Reference(s):1. Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease (2017)2. BOT-4-one attenuates NLRP3 inflammasome activation: NLRP3 alkylation leading to the regulation of its ATPase activity and ubiquitination (2017)

• Artikelnummer: BPS100190
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 100190
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK