Novobiocin , CAS 1476-53-5

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Biological Activity: Novobiocin has been shown to inhibit bacterial DNA gyrase supercoiling with an IC50 of 0.08 µM

CAS Number: 1476-53-5

Description: Novobiocin is an aminocoumarin antibiotic that is produced by Streptomyces niveus. Along with other aminocoumarin antibiotics, novobiocin is a very potent inhibitor of bacterial DNA gyrase. It works by targeting the GyrB subunit of the enzyme involved in energy transduction.

Format: A red aqueous solution

Purity: ≥93% by HPLC

Storage Stability: Store at or below -20°C and avoid multiple freeze-thaw cycles to prevent decomposition.

Supplied As: 400 µM solution in anhydrous DMSO

Warnings: Avoid freeze/thaw cycles.

Biosafety Level: Not applicable (BSL-1)

References: 1. Lamour V, et al., J Biol Chem. 2002 May 24;277(21):18947-53.
2. Alt, S., et al., J Antimicrob Chemother. 2011 Jun 11; doi:10.1093/jac/dkr247.

• Artikelnummer: BPS27501
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 27501
• Green Labware: Nein
• Verpackungseinheit: 250 µl
• Mengeneinheit: STK