Abbreviation: NR3C2
Target Synonym: NR3C2;MCR;MLR;MR;NR3C2VIT
Conjugation: Unconjugated
UNIProt ID: P08235
Background: This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
Concentration: 1mg/mL
Immunogen: Recombinant fusion protein of human Mineralocorticoid receptor
Dilution: WB 1:500-1:2000,IHC 1:50-1:200,IF 1:50-1:200