NS 13001, CAS 1063331-94-1

Formulation: A solid

Formal Name: N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine

Purity: ≥98%

Formula Markup: C17H16ClN7

Formula Weight: 353,8

Shelf life (days): 1460

CAS Number: 1063331-94-1

Notes: NS 13001 is a positive allosteric modulator for small-conductance calcium-activated potassium channel 2 (KCa2.2/SK2) and KCa2.3/SK3.{51239} It increases calcium-induced currents in an inside-out patch clamp assay using HEK293 cells expressing human KCa2.2/SK2 or KCa2.3/SK3 (EC50s = 1.8 and 0.14 µM, respectively). Oral administration of NS 13001 (30 mg/kg per day) improves sensorimotor deficits in the beam walk test and increases the latency to fall in the rotarod test in a SCA2-58Q transgenic mouse model of neuromuscular degeneration.

• Artikelnummer: CAY37317-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 37317-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK
• Methode: Reinstoffe