NS 3728, CAS 265646-85-3

Formulation: A solid

Formal Name: N-[3,5-bis(trifluoromethyl)phenyl]-N′-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-urea

Purity: ≥95%

Formula Markup: C16H9BrF6N6O

Formula Weight: 495,2

Shelf life (days): 1460

CAS Number: 265646-85-3

Notes: NS 3728 is a chloride channel inhibitor.{68007,72308} It inhibits the volume-regulated anion channel (VRAC) in HEK293 cells and chloride conductance in washed isolated human erythrocytes (IC50s = 0.4 and 0.6 µM, respectively).{68007} NS 3728 also inhibits calcium-activated chloride currents in Ehrlich-Lettre ascites carcinoma cells (IC50s = 2.11 and 0.7 µM at +95 and -50 mV, respectively).{72308} It reduces the proliferation of Ehrlich-Lettre ascites cells and inhibits IFN-γ-induced nitric oxide (NO) production in BV-2 microglia (IC50s = 0.52 and 3.7 µM, respectively).{72308,72309}

• Artikelnummer: CAY39988-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39988-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK