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NSD2 (catalytic domain), GST-tag Recombinant
NSD2 (catalytic domain), GST-tag Recombinant
Artikelnummer
BPS51026
Verpackungseinheit
50 µg
Hersteller
BPS Bioscience
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Encompassing Amino Acids: 941-1240
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay was performed using the BPS NSD2 Chemiluminescent Assay Kit (Cat. #53009) according to recommended protocol, with 5 µM S-adenosylmethionine on biotinylated H3 peptide-coated plates. Enzyme reaction was performed for 2 hours at room temperature.
Background: NSD2 is a histone methyltransferase that preferentially methylates Lys27 of histone H3. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Mutations in the gene for NSD2 are linked to Wolf-Hirschhorn syndrome (WHS), a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4, and is also associated with chromosomal translocations in multiple myelomas.
Description: Human NSD2, also known as RE-IIBP, MMSET, and WHSC1 (GenBank Accession No. NM_133330), a.a. 941-1240 (catalytic domain) with N-terminal GST-tag, MW = 62 kDa, expressed in E. coli.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 8.5, 300 mM NaCl, 5 mM DTT, 10 mM glutathione, and 10% glycerol.
Genbank: NM_133330
Host Cell Line: E. coli
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: O96028
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kassambara A. et al., Biochem. Biophys. Res. Commun. 379 (4), 840-845 (2009).
2. Brito J.L. et al., Haematologica 94 (1), 78-86 (2009).
Encompassing Amino Acids: 941-1240
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Assay Conditions: Assay was performed using the BPS NSD2 Chemiluminescent Assay Kit (Cat. #53009) according to recommended protocol, with 5 µM S-adenosylmethionine on biotinylated H3 peptide-coated plates. Enzyme reaction was performed for 2 hours at room temperature.
Background: NSD2 is a histone methyltransferase that preferentially methylates Lys27 of histone H3. Isoform RE-IIBP may act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment. Mutations in the gene for NSD2 are linked to Wolf-Hirschhorn syndrome (WHS), a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4, and is also associated with chromosomal translocations in multiple myelomas.
Description: Human NSD2, also known as RE-IIBP, MMSET, and WHSC1 (GenBank Accession No. NM_133330), a.a. 941-1240 (catalytic domain) with N-terminal GST-tag, MW = 62 kDa, expressed in E. coli.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 8.5, 300 mM NaCl, 5 mM DTT, 10 mM glutathione, and 10% glycerol.
Genbank: NM_133330
Host Cell Line: E. coli
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: O96028
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Kassambara A. et al., Biochem. Biophys. Res. Commun. 379 (4), 840-845 (2009).
2. Brito J.L. et al., Haematologica 94 (1), 78-86 (2009).
| Artikelnummer | BPS51026 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 51026 |
| Green Labware | Nein |
| Verpackungseinheit | 50 µg |
| Mengeneinheit | STK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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Gernot Ensinger, M.Sc.
Laurent Haze
