Occludin (Marker of Early Blood Brain Barrier Damage)(OCLN/2181), 1mg/mL

Occludin (Marker of Early Blood Brain Barrier Damage)(OCLN/2181), 1mg/mL
Artikelnummer
BTMBNUM2181-50
Verpackungseinheit
50 uL
Hersteller
Biotium

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Description: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structural component of the blood-brain barrier (BBB). Degradation of Occludin is frequently seen in ischemic stroke and contributes to BBB disruption. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, BSA-free

Concentration: 1 mg/mL

Storage buffer: PBS, no BSA, no azide

Product Origin: Animal - Mus musculus (mouse)

Clone: OCLN/2181

Entrez Gene ID: 100506658

Immunogen: Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary)

Verified AB Applications: IHC (FFPE) (verified)/WB (verified)

Z-Antibody Applications: IHC, FFPE (verified)/WB (verified)
Mehr Informationen
Artikelnummer BTMBNUM2181-50
Hersteller Biotium
Hersteller Artikelnummer BNUM2181-50
Verpackungseinheit 50 uL
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Western Blotting, Immunohistochemistry
Isotyp IgG1 kappa
Wirt Mouse
Konjugat Unconjugated
Produktinformation (PDF) Download
MSDS (PDF) Download