P32/98, CAS 136259-20-6

DPPIV/DPP4 inhibitor

Product Type: Inhibitor

CAS No.: 136259-20-6

MolecularFormula: C9H18N2OS•0.5C4H4O4

Molecular Weight: 260,4

Source: Synthetic

Purity: >98%

Solubility: Soluble in water (20 mg/ml) or DMSO (25 mg/ml)

Appearance: White solid

PubChem CID: 77519185

Scientific Background: P32/98 (Ile-thiazolidide) is a specific, competitive transition-state substrate analog inhibitor of dipeptidyl peptidase IV (DPIV; DPPIV; CD26), with a Ki of 130 nM (1-3). Useful in diabetes research. Has been used in vivo (10mg/kg orally twice daily)(4-7) and in tissue culture (1-10 µM) (8).

References: 1. Schön E., et al. (1991) Biol. Chem. Hoppe Seyler. 372(5): 305-11. 2. Pederson R.A., et al. (1998) Diabetes. 47(8): 1253-8.3. Lankas G.R., et al. (2005) Diabetes. 54(10): 2988-94.4. Pospisilik J.A., et al. (2002) Diabetes. 51(4): 943-50.5. Pospisilik J.A., et al. (2002) Diabetes. 51(9): 2677-83. 6. Pospisilik J.A., et al. (2003) Diabetes. 52(3): 741-50. 7. Meyer A., et al. (1993) J. Chromatogr. B. 796(2): 401-11. 8. Girardi A.C.C., et al. (2004) Am. J. Physiol. Cell. Physiol. 287(5): C1238-45.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-385-10MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-385-10MG
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK