Product Type: Activator
CAS No.: 315183-21-2
MolecularFormula: C23H28N4O2
Molecular Weight: 392,5
Source: Synthetic
Purity: >98% (HPLC); NMR (Conforms)
Solubility: May be dissolved in DMSO (35 mg/ml); or ethanol (15 mg/ml)
Appearance: Off-White powder
PubChem CID: 9675990
Scientific Background: PAC-1 is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3 (1); it is less potent at activating procaspase-7. It induces apoptosis in a variety of cancer cell lines by activation involving sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate (2).
References: 1. Putt K.S., et al., (2006) Nat. Chem. Biol. 2:543.2. Peterson Q.P., et al., (2009) J. Mol. Biol. 388:144.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.