PAF Receptor (human) Monoclonal Antibody (11A4, Clone 21)

Formulation: 100 µg of protein A-purified monoclonal antibody

Immunogen: Synthetic peptide from the internal region of human PAF receptor

Clone Designation: 11A4, Clone 21

Shelf life (days): 1095

Notes: PAF is a potent phospholipid mediator which exerts diverse biological actions by interaction with a G protein-coupled PAF receptor. The PAF receptor has been cloned from a number of species including human, rat, and guinea pig and is characterized as a 7-transmembrane receptor which induces phosphoinositol turnover through G-protein coupling.{5109,5148,5150,5145,5149} Northern blot analysis reveals that the receptor is expressed in leukocytes, placenta, lung, spleen, small intestine, kidney, liver, and brain.{5150,5145} In leukocyte cell populations the receptor is found on platelets, monocytes, neutrophils, and B-cells, whereas resting T-cells and natural killer cell lines do not express the PAF receptor.{4226} Human monocytes treated with INF-γ have a 2-6 fold increase in PAF receptor expression compared to untreated cells.{4225}

• Artikelnummer: CAY160600-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 160600-100
• Green Labware: Nein
• Verpackungseinheit: 1 ea (100 µg)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: ELISA, Flow Cytometry, Immunocytochemistry
• Isotyp: IgG2a
• Wirt: Mouse