PAMAM Dendrimer G1.5 Carboxylate (sodium salt) (water solution), CAS 251970-28-2

Formulation: A solution in water

Formal Name: 18,21-bis[3-[[2-[bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]amino]ethyl]amino]-3-oxopropyl]-11,28-bis[3-[[2-[bis(2-carboxyethyl)amino]ethyl]amino]-3-oxopropyl]-4,35-bis(2-carboxyethyl)-8,15,24,31-tetraoxo-4,7,11,14,18,21,25,28,32,35-decaazaoctatriacontanedioic acid, hexadecasodium salt

Formula Markup: C110H176N26O44 • 16Na

Formula Weight: 2934,6

Shelf life (days): 730

CAS Number: 251970-28-2

Notes: PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini.{67552} It is approximately 36.2 Å in diameter in water and has 12 surface groups.{67554} PAMAM G1.5 (10 µM) inhibits plaque formation induced by Middle East respiratory syndrome coronavirus (MERS-CoV) in Vero cells.{67552} Conjugates of PAMAM G1.5 with the active fragment of the DNA cross-linking agent oxaliplatin (Item No. 13106) are cytotoxic to A2780 ovarian, MCF-7 breast, and Caco-2 colon cancer cells and BJ fibroblasts (IC50s = 0.04, 1.6, 0.3, and 1.3 µM, respectively).{67553}

• Artikelnummer: CAY39106-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39106-1
• Verpackungseinheit: 1 g
• Mengeneinheit: STK