PAMAM Dendrimer G5.0 Amine (water solution), CAS 163442-68-0

Formulation: A solution in water

Formula Markup: [NH2(CH2)2NH2]:(G=5);dendri PAMAM(NH2)128

Formula Weight: 28824,8

Shelf life (days): 730

CAS Number: 163442-68-0

Notes: PAMAM dendrimer G5.0 amine (PAMAM G5.0) is a polyamidoamine (PAMAM) dendrimer with amine termini.{51536} It is approximately 54 Å in diameter and has 128 surface groups. PAMAM G5.0 (10 µg/ml) reduces viability, induces cell cycle arrest at the sub-G1/M phase, and increases lactate dehydrogenase (LDH) release from RAW 264.7 macrophages.{68596} It also induces DNA fragmentation in the same cells when used at a concentration of 15 µg/ml. PAMAM G5.0 in complex with siRNA targeting Pou5f1 mRNA, the gene encoding Oct4, reduces Oct4 expression in mouse embryonic stem cells.{68597} Intravenous administration of PAMAM G5.0 in complex with reporter gene DNA increases reporter gene expression in the lung, spleen, and liver, but not the heart, in mice.{68598} Conjugates of PAMAM G5.0 with the contrast agent gadolinium increases small vessel contrast quality compared to conjugates of gadolinium with the cell-impermeable metal chelating agent diethylenetriaminepentaacetic acid (DTPA; Item No. 33307).{68599}

• Artikelnummer: CAY39075-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39075-500
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK