Product Description: Paroxetine is an oral inhibitor that falls under the category of selective serotonin reuptake inhibitors (SSRIs). Paroxetine is also a very weak norepinephrine (NE) reuptake inhibitor, capable of inducing cell apoptosis and having anti-tumor activity. Paroxetine has antidepressant, anti-anxiety, and pain-relieving effects, and it can help improve conditions like obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, premenstrual anxiety, and chronic headaches[1][2][3][4].
Applications: Neuroscience-Neuromodulation
Formula: C19H20FNO3
Citations: Biochem Biophys Res Commun. 2024 Jun 13:725:150263./Front Pharmacol. 22 June 2022./Autophagy. 2024 Dec 11./Brain Res. 2019 Oct 1;1720:146296. /Cell. 2021 Apr 15;184(8):2167-2182.e22./Front Pharmacol. 2024 Jul 31:15:1389761./J Chem Inf Model. 2021 Jul 21./J Mol Cell Cardiol Plus. 2024 Jun, 8, 100072.
References: [1]M Bourin, et al. Paroxetine: a review. CNS Drug Rev. Spring 2001;7(1):25-47/[2]Young-Woo Cho, et al. Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca2+-and p38 MAP Kinase-Dependent ROS Generation. Cancers (Basel). 2019 Jan 9;11(1):64./[3]Malek Zarei, et al. Paroxetine attenuates the development and existing pain in a rat model of neurophatic pain. Iran Biomed J. 2014;18(2):94-100./[4]S Lightowler, et al. Anxiolytic-like effect of paroxetine in a rat social interaction test. Pharmacol Biochem Behav. 1994 Oct;49(2):281-5.
CAS Number: 61869-08-7
Molecular Weight: 329.371
Compound Purity: 99.94
Research Area: Cancer; Neurological Disease
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Adrenergic Receptor;Apoptosis;P2X Receptor;Serotonin Transporter
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