Product Description: PC190723 is a bacterial cell division protein FtsZ inhibitor with an IC50 of 55 ng/mL. PC190723 has bactericidal activity against B. subtilis and a variety of staphylococci, with MIC ranging from 0.5 and 1.0 μg/mL. PC190723 exerts antibacterial activity by enhancing FtsZ polymer assembly and inhibiting depolymerization[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C14H8ClF2N3O2S
References: [1]Buroni S, et al. The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem. 2020 Mar 15;190:112132. /[2]Haydon DJ, et al. An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science. 2008 Sep 19;321(5896):1673-5. /[3]Andreu JM, et al. The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation. J Biol Chem. 2010 May 7;285(19):14239-46.
CAS Number: 951120-33-5
Molecular Weight: 355.75
Compound Purity: 98.34
Research Area: Infection
Solubility: DMSO : 200 mg/mL (ultrasonic)
Target: Bacterial
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