PCSK9 (human) Monoclonal Antibody (Clone 15A6)

Formulation: 500 µg of affinity-purified monoclonal antibody

Immunogen: Purified human recombinant PCSK9

Clone Designation: 15A6

Shelf life (days): 1095

Notes: Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism.{13178} Gain-of-function mutations in the PCSK9 gene are associated with autosomal dominant hypercholesterolemia which is characterized by an increase in low-density lipoprotein (LDL) cholesterol levels.{13158} PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through accelerated LDL receptor degredation.{13178,13176} PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscle with the highest expression in the liver.{13136} Human PCSK9 precursor is 692 amino acids in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein at around 63 kDa in the Golgi body.{13177}

• Artikelnummer: CAY10218-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10218-500
• Green Labware: Nein
• Verpackungseinheit: 1 ea (500 µg)
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Western Blotting
• Isotyp: IgG1
• Wirt: Mouse