PD-L1/CD274 Polyclonal Antibody, Rabbit

Abbreviation: PD-L1/CD274

Target Synonym: CD274; B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1; CD274 molecule

Conjugation: Unconjugated

UNIProt ID: Q9NZQ7

Background: This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

Concentration: 1mg/mL

Immunogen: Recombinant fusion protein of human PD-L1/CD274

Dilution: WB 1:500-1:2000,IHC 1:50-1:200

• Artikelnummer: ELSE-AB-92367-60
• Hersteller: Elabscience Biotechnology
• Hersteller Artikelnummer: ELA-E-AB-92367-60
• Green Labware: Nein
• Verpackungseinheit: 60 µl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine)
• Klonalität: Polyclonal
• Methode: Western Blotting, Immunohistochemistry
• Isotyp: IgG
• Wirt: Rabbit