PD98059, CAS 167869-21-8

MEK kinase inhibitor

Product Type: Inhibitor

CAS No.: 167869-21-8

MolecularFormula: C16H13NO3

Molecular Weight: 267,3

Source: Synthetic

Purity: >98% (HPLC); NMR (Conforms)

Solubility: May be dissolved in DMSO (6mg/mL)

Appearance: Pale yellow solid

PubChem CID: 4713

Scientific Background: PD98059 is a potent, selective and reversible inhibitor of mitogen-activated protein kinase kinase (MAPKK/ MEK-1) activation. Specifically, it binds to the inactive form of MAPKK, blocking its activation, causing inhibition of phosphorylation and the activation of MAP kinase. It has been shown to enhance self-renewal of embryonic stem cells. PD98059 is cell permeable inhibitor.

References: 1. Alessi D.R., Cuenda A., Cohen P., Dudley D.T., & Saltiel A.R. (1995) J. Biol. Chem. 270(46): 27489–27494.2. Qi X., et al. (2004) Pro. Nat. Acad. Sci. USA. 101(16): 6027–6032. 3. Dudley D.T., Pang L., Decker S.J., Bridges A.J., & Saltiel A.R. (1995) Pro. Nat. Acad. Sci. USA. 92(17): 7686–7689.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-466-5MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-466-5MG
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK