Permethrin-d9

Formulation: A solution in acetonitrile

Formal Name: 3-(2,2-dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid, (3-phenoxyphenyl)methyl ester-d9

Purity: ≥99% deuterated forms (d1-d9)

Formula Markup: C21H11D9Cl2O3

Formula Weight: 400,3

Shelf life (days): 730

Notes: Permethrin-d9 is intended for use as an internal standard for the quantification of permethrin (Item No. 23821) by GC- or LC-MS. Permethrin is a modulator of voltage-gated sodium channels (NaV) that is used as an insecticide.{36375} It delays channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. It is at least 100-fold more potent at insect than mammalian sodium channels, leading to slow deactivation of D. para/TipE, but not rat brain IIA or β1, sodium channels expressed in X. laevis oocytes when used at a concentration of 500 nM.{36376} Permethrin (5 µM) increases sodium influx in BV-2 and primary microglial cells by approximately 28 and 29%, respectively, and activates microglia.{36377} Long-term application of permethrin leads to dose- and time-dependent intracellular sodium accumulation and TNF-α release in microglia in vitro. Formulations containing permethrin have been used for the treatment of head lice and scabies infestations.

• Artikelnummer: CAY39585-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39585-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung