PF-04979064, CAS 1220699-06-8

Formulation: A solid

Formal Name: 1,3-dihydro-1-[1-[(2S)-2-hydroxy-1-oxopropyl]-4-piperidinyl]-3-methyl-8-(6-methyl-3-pyridinyl)-2H-imidazo[4,5-c][1,5]naphthyridin-2-one

Purity: ≥98%

Formula Markup: C24H26N6O3

Formula Weight: 446,5

Shelf life (days): 1460

CAS Number: 1220699-06-8

Notes: PF-04979064 is a dual inhibitor of PI3K and mTOR (Kis = 0.13, 0.111, 0.122, and 1.42 nM for PI3Kα, PI3Kγ, PI3Kδ, and mTOR, respectively).{51505} It is selective for PI3K and mTOR over a panel of 36 other kinases at 1 µM. PF-04979064 inhibits phosphorylation of Akt in BT-20 breast cancer cells (IC50 = 9.1 nM). It reduces tumor volume by 88% in a U87MG glioblastoma mouse xenograft model when administered at a dose of 40 mg/kg. PF-04979064 also increases alveolar epithelial cell apoptosis in a mouse model of chronic obstructive pulmonary disease (COPD) induced by fine particulate matter less than 2.5 µm (PM2.5).{51504}

• Artikelnummer: CAY39527-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39527-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK