Phosphatidylserine (bovine), CAS 1446756-47-3

Formulation: A solution in chloroform

Purity: ≥98%

Formula Markup: C42H78NO10P (for oleoyl)

Formula Weight: 788,1

Shelf life (days): 730

CAS Number: 1446756-47-3

Notes: Phosphatidylserine is a naturally occurring phospholipid that comprises 2-10% of total phospholipids in mammals and is enriched in the central nervous system, particularly the retina.{38744} It is anionic and found mainly on the inner leaflet of the cell membrane. It is biosynthesized from phosphatidylcholine (Item Nos. 24343 / 24370) or phosphatidylethanolamine (Item No. 24332) by phosphatidyl synthase 1 (PSS1) or PSS2, respectively, in the endoplasmic reticulum and can be reversibly converted back by the same enzymes. It can also be irreversibly converted to phosphatidylethanolamine by phosphatidylserine decarboxylase in the mitochondria. Phosphatidylserine binds to T cell immunoglobulin mucin type 1 (TIM-1) and TIM-4 receptors as well as brain-specific angiogenesis inhibitor 1 (BAI1), leading to anti-inflammatory and anti-atherosclerotic effects.{38745} It is also a cofactor involved in the activation of various signaling pathways through activation of protein kinase C, neutral sphingomyelinase, and c-Raf-1 protein kinase among others.{38744} Phosphatidylserine is externalized during apoptosis by scramblases in the plasma membrane as a signal for phagocytes to engulf the cell.{38746} This product contains phosphatidylserine molecular species with primarily C18:0 fatty acyl chain lengths. [Matreya, LLC. Catalog No. 1047]

• Artikelnummer: CAY24341-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 24341-50
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK