Piccolo Antibody, Clone 6H9-B6: RPE

Mouse Anti-Human Piccolo Monoclonal IgG2b Kappa

Target: Piccolo

Conjugate: RPE

Product Type: Monoclonal

Clone Number: 6H9-B6

Immunogen: Human full length recombinant protein (GenBank ID: BC001304.1)

Swiss-Prot: Q9QYX7

Purification: Protein G Purified

Storage Buffer: PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

Concentration: 1 mg/ml

Specificity: Detects ~550kDa. No cross-reactivity to Bassoon.

Cellular Localization: Cell Junction,Synapse

Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).

References: 1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619.2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162.3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSMC-188D-RPE
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SMC-188D-RPE
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus)
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, ELISA, Immunocytochemistry
• Isotyp: IgG2b kappa
• Human Gene ID: 26875
• Wirt: Mouse