Picropodophyllotoxin, CAS 477-47-4

IGF1R inhibitor

Product Type: Inhibitor

CAS No.: 477-47-4

MolecularFormula: C22H22O8

Molecular Weight: 414,4

Source: Synthetic

Purity: ≥96% (HPLC)

Solubility: Soluble in DMSO (10 mg/ml, warm) or dimethyl formamide (25 mg/ml)

Appearance: White solid

PubChem CID: 72435

Scientific Background: Picropodophyllotoxin is an inhibitor of insulin-like growth factor 1 receptor (IGF1R). Specifically, it inhibits IGF1R autophosphorylation. It has also been seen to increases the fraction of cells in the G2/M phase, reduce pAKT and pERK1/2, and upregulates apoptosis. Picropodophyllotoxin exhibits antiproliferative effects in multiple cancer cell lines.

References: 1. Girnita A., et al. (2004) Cancer Res. 64(1): 236–242.2. Strömberg T., et al. (2006) Blood. 107(2): 669–678.

Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• Artikelnummer: STRSIH-467-25MG
• Hersteller: Stressmarq Biosciences
• Hersteller Artikelnummer: SIH-467-25MG
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK