Solubility: Soluble in ethanol (110 mM) and in DMSO (110 mM)
Appearance: White to off-white solid
PubChem CID: 327653
Scientific Background: Selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
References: 1. Leu J.L., et al. (2009) Mol. Cell. 36: 15.
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.