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PIM2, GST-tag Recombinant
PIM2, GST-tag Recombinant
Artikelnummer
BPS40153
Verpackungseinheit
10 µg
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Encompassing Amino Acids: full length
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon (1). It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate (2).
Description: Recombinant human PIM2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_006875
Host Cell Line: Sf9 cells
Purity: ≥75%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q9P1W9
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Baytel, D. et al. Biochim. Biophys. Acta 1442: 274-285, 1998.
2. Yan, B. et al. J Biol Chem. 2003 Nov 14;278(46):45358-67.
3. Neri P, Bahlis NJ. Blood. 2013 Aug 29;122(9):1534-6.
4. Blanco-Aparicio C, Carnero A. Biochem Pharmacol. 2013 Mar 1;85(5):629-43.
Encompassing Amino Acids: full length
Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Background: PIM2 is a serine threonine kinase that is present in all tissues, being most abundant in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon (1). It is highly expressed in human leukemic, lymphoma and colorectal adenocarcinoma cell lines. This suggests a role for PIM2 in proliferating cells as well as during meiosis. Similar to PIM1, PIM2 also acts as a pro-survival kinase and BAD protein is a legitimate PIM2 substrate (2).
Description: Recombinant human PIM2, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.
Format: Aqueous buffer solution
Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol.
Genbank: NM_006875
Host Cell Line: Sf9 cells
Purity: ≥75%
Storage Stability: At least 6 months at -80°C.
Tags: N-terminal GST-tag
Uniprot: Q9P1W9
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Baytel, D. et al. Biochim. Biophys. Acta 1442: 274-285, 1998.
2. Yan, B. et al. J Biol Chem. 2003 Nov 14;278(46):45358-67.
3. Neri P, Bahlis NJ. Blood. 2013 Aug 29;122(9):1534-6.
4. Blanco-Aparicio C, Carnero A. Biochem Pharmacol. 2013 Mar 1;85(5):629-43.
| Artikelnummer | BPS40153 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 40153 |
| Green Labware | Nein |
| Verpackungseinheit | 10 µg |
| Mengeneinheit | STK |
| Wirt | Insect |
| Produktinformation (PDF) |
|
| MSDS (PDF) |
|
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