PLCE1 antibody

Application Note: WB: 1:500-1:2000. ICC/IF: 1:100-1:500. IHC-P: 1:50-1:200. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 259

Form: Liquid

Buffer (with preservative): PBS, 150mM NaCl, 50% Glycerol, 0.02% Sodium azide.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]

Uniprot ID: Q9P212

Antigen Species: Human

Immunogen: A synthesized peptide derived from human PLCE1, corresponding to a region within C-terminal amino acids.

Purification: Purified by antigen-affinity chromatography

Conjugation: Unconjugated

Full Name: phospholipase C epsilon 1

• Artikelnummer: GTX02580-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX02580-100
• Green Labware: Nein
• Verpackungseinheit: 100 μl
• Mengeneinheit: STK
• Reaktivität: Human, Mouse (Murine), Rat (Rattus), Monkey (Primate)
• Klonalität: Polyclonal
• Methode: Immunofluorescence, Immunohistochemistry (paraffin), Western Blotting, Immunocytochemistry
• Isotyp: IgG
• Human Gene ID: 51196
• Wirt: Rabbit