POLH antibody (5H10)

Clone Name: 5H10

Light Chain: Kappa

Application Note: WB: 1:500-1:2000. ICC/IF: 1:200-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Calculated MW: 78

Form: Liquid

Buffer (with preservative): Filter-sterilized PBS, 50% Glycerol, no preservative.

Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)

Background: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot ID: Q9Y253

Antigen Species: Human

Immunogen: Human recombinant full-size Pol eta tagged with His6

Purification: Purified by salting-out and ion-exchange chromatography

Conjugation: Unconjugated

Full Name: DNA polymerase eta

• Artikelnummer: GTX00871-100
• Hersteller: GeneTex
• Hersteller Artikelnummer: GTX00871-100
• Green Labware: Nein
• Verpackungseinheit: 100 μg
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Immunofluorescence, Western Blotting, Immunocytochemistry
• Isotyp: IgG1
• Human Gene ID: 5429
• Wirt: Mouse